Protein Glycation, Diabetes, and Aging
نویسندگان
چکیده
منابع مشابه
Protein glycation, diabetes, and aging.
Biological amines react with reducing sugars to form a complex family of rearranged and dehydrated covalent adducts that are often yellow-brown and/or fluorescent and include many cross-linked structures. Food chemists have long studied this process as a source of flavor, color, and texture changes in cooked, processed, and stored foods. During the 1970s and 1980s, it was realized that this pro...
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Glycation and oxidation are two mechanisms that have been widely attributed with the generation of advanced glycation end products upon proteins in various pathological conditions. Histones being lysine and arginine rich are prone to these reactions and hence they are susceptible to glycoxidation reactions. Post translational modifications in the highly conserved basic core histone proteins are...
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Metabolic alterations of diabetes mellitus are not only informative biological signs, but also factors of degenerative complications. Thus, hyperglycaemia increases non enzymatic glycation, characterized by the binding of simple oses (glucose) or by-products to amino groups of proteins. This reaction leads to the formation of complex compounds, advanced glycation end products (AGEs), which alte...
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Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibition of AGE forma...
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This article reviews glycation stress as a factor linked to age-related diseases and functional and structural alterations of the skin. Photo-aging and glycation stress are major causes of skin deterioration. Glycation occurs when a reducing sugar, such as glucose or fructose, combines with a protein in a non-enzymatic reaction forming a glycated protein. Further reactions form advanced glycati...
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ژورنال
عنوان ژورنال: Recent Progress in Hormone Research
سال: 2001
ISSN: 0079-9963
DOI: 10.1210/rp.56.1.1